Specific cerebral circuitry bridges chemical changes deep in the brain and the more outward behavioral expressions associated with post-traumatic stress disorder (PTSD), which could lead to more objective biomarkers for the disorder, according to a comprehensive review of rapidly changing data published June 22 in the New England Journal of Medicine.
In this latest, comprehensive review, the authors – from the Steven and Alexandra Cohen Veterans Center (CVC) in the Department of Psychiatry at NYU Langone Medical Center and the University of Michigan/Veterans Affairs Ann Arbor Health Systems Mental Health Service – have identified four neural-behavioral models associated with PTSD. These models pinpoint specific circuits in the brain that “mediate” between chemical changes – which are being examined as possible PTSD biomarkers – and the expression of certain characteristics often associated with PTSD. These include fear responses, avoidance of trauma reminders, impaired emotional balance and the persistence of defensive responses despite a safe environment.
Read more in the original article at https://www.sciencedaily.com/releases/2017/06/170621190040.htm
